Role of the NALP3 inflammasome in CS-driven model.

<p>NALP3 or ASC ^-/- mice were exposed to CS or room air (control) twice daily for 3 consecutive days alongside wild-type controls. BALF and lung tissue was collected 24 hours after the last exposure for measurement of IL-1β (A), neutrophil (B), IL-1α (C), caspase 1 activity (D) and KC (E) levels. Data are represented as mean ± S.E.M. for n = 8 animals in each group. Statistical significance was determined using Mann-Whitney U test. # = P<0.05, denoting a significant difference between the smoke exposed and air exposed wild-type groups; * = P<0.05, denoting a significant difference between the smoke exposed knock-outs and wild-types (one-way ANOVA).