Characterization by genome-wide profiling of the transcriptome associated with TIA-silenced HeLa cells.

<p>(<b>A</b>) MA plot representation of the distribution of up- (spots in red) and down- (spots in green) regulated RNAs (–1.5≥ fold-change ≤1.5; FDR<0.05) in TIA1 and TIAR-silenced <i>versus</i> control HeLa cells. (<b>B</b> and <b>C</b>) Histograms of the distribution of up- (red) and down- (green) regulated genes using the GO (<b>B</b>) and KEGG (<b>C</b>) databases (<i>P</i><0.05) in TIA1 and TIAR-silenced HeLa cells. (<b>D</b>) Comparison between RNA-seq and genome-wide array data. Venn diagrams depicting the numbers of genes that were up- (red) and down- (green) regulated as well as those shared in TIA1 or/and TIAR-knocked down HeLa cells.