MaR1 attenuates TNF-α induced expression of NADPH-oxidases.

<p>VSMC (A, B) and EC (C, D) were treated with 100 nM of MaR1 for 30 min, followed by TNF-α for 6 hr. After TNF-α treatment, cells were lysed and probed for NOX-4, NOX-1 and NOX-2. (A) N = 14 per group, (B) N = 17 per group, (C) N≥7 per group, (D) N = 3 per group. *:p≤0.05 compared to vehicle control, †: p≤0.05 compared to TNF-α alone (t-test). N = each well of a 6-well plate. Error bar = SEM.