<p>Panel A: Absolute fitness of 13 Φ6 host range mutants on the novel host, ERA. Each point is the mean of 5 replicate measurements of fitness. Bars are ±1SE. Panel B: Absolute fitness of 13 Φ6 host range mutants on the canonical host, PP. Each point is the mean of 5 replicate measurements of fitness. Fitness of wildtype Φ6 is shown by the dotted line for comparison. Bars are ±1SE.</p
<p>Panels in the upper row show averaged allele frequency dynamics over 25 generations after an alle...
<p>(A) The average number of escape (solid) and deleterious (dashed) mutations at the end of the acu...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...
<p><b>A</b>) Fraction of viable and non-viable mutants in each group. <b>B</b>) Relative fitness of ...
<p><b>A</b>) Relative fitness of the 21 viable mutants in CEMx174 cells. Values shown are an average...
<p>The Δ4904 single mutant was outcompeted by the wild type. <b>Panels A, B</b> and <b>C</b> depict ...
<p>(A) Viability of all CA mutant clones at 35°C (this excludes nonsense mutations, duplicates, fram...
<p>Panel (a) represents the mutational map. There are lethal sites on the genome, and 2 adaptive si...
<p>A: production of host offspring (fecundity) over 25 days; B: survival of hosts; and C: instantane...
<p>(A) A heat map showing the profile of relative fitness represented as selection coefficient (<i>s...
<p>(A) Pathogen longevity (1/<i>d<sub>V</sub></i>) – Mutation probability (<i>x</i>) and (B) Yield s...
We describe a sensitive, internally controlled method for comparing the genetic adaptability and rel...
<p>(A) Pathogen longevity (1/<i>d<sub>V</sub></i>) – Mutation probability (<i>x</i>) and (B) Yield s...
<p>Bar heights indicate the mean of three replicate competitions; error bars denote standard deviati...
<p>A) The 6 wildtype replicates that are cultured on MT4 T-cells show a linear increase in fitness. ...
<p>Panels in the upper row show averaged allele frequency dynamics over 25 generations after an alle...
<p>(A) The average number of escape (solid) and deleterious (dashed) mutations at the end of the acu...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...
<p><b>A</b>) Fraction of viable and non-viable mutants in each group. <b>B</b>) Relative fitness of ...
<p><b>A</b>) Relative fitness of the 21 viable mutants in CEMx174 cells. Values shown are an average...
<p>The Δ4904 single mutant was outcompeted by the wild type. <b>Panels A, B</b> and <b>C</b> depict ...
<p>(A) Viability of all CA mutant clones at 35°C (this excludes nonsense mutations, duplicates, fram...
<p>Panel (a) represents the mutational map. There are lethal sites on the genome, and 2 adaptive si...
<p>A: production of host offspring (fecundity) over 25 days; B: survival of hosts; and C: instantane...
<p>(A) A heat map showing the profile of relative fitness represented as selection coefficient (<i>s...
<p>(A) Pathogen longevity (1/<i>d<sub>V</sub></i>) – Mutation probability (<i>x</i>) and (B) Yield s...
We describe a sensitive, internally controlled method for comparing the genetic adaptability and rel...
<p>(A) Pathogen longevity (1/<i>d<sub>V</sub></i>) – Mutation probability (<i>x</i>) and (B) Yield s...
<p>Bar heights indicate the mean of three replicate competitions; error bars denote standard deviati...
<p>A) The 6 wildtype replicates that are cultured on MT4 T-cells show a linear increase in fitness. ...
<p>Panels in the upper row show averaged allele frequency dynamics over 25 generations after an alle...
<p>(A) The average number of escape (solid) and deleterious (dashed) mutations at the end of the acu...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...