Palladium-Catalyzed Sequential C–N/C–O Bond Formations: Synthesis of Oxazole Derivatives from Amides and Ketones

A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones has been established via a Pd­(II)-catalyzed sp² C–H activation pathway in one step. The reaction is supposed to proceed through a C–N bond formation followed by a C–O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly applied to medical chemistry