Down regulated PDI attenuates CNP-mediated cGMP activation in HMCs.
- Shuchong Pan (665103)
- Horng H. Chen (282940)
- Cristina Correia (193836)
- Haiming Dai (665104)
- Tyra A. Witt (665105)
- Laurel S. Kleppe (665106)
- John C. Burnett Jr (282938)
- Robert D. Simari (136553)
Publication date
November 2014
DOIAbstract
<p><b>A</b>. Western blotting with RL90 antibody shows partial knockdown of PDI in HMCs. <b>B</b>. Effect of PDI knockdown on cGMP activation. Data are expressed as mean<u>+</u>SEM vs control cells without PDI siRNA treatment (*P≤0.05). <b>C</b>. PDI inhibition by RL90 decreases ANP, BNP and CNP-mediated cGMP generation in HMC (*p≤0.05). (Error bars, +SD from 3 independent experiments, samples were triplicated in each experiment).</p
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