Transcription of inflammatory mediators in the liver of infected mice.

<p>C57BL/6J mice were left uninfected or were infected with <i>Pb</i>ANKA, <i>Pb</i>NK65 or <i>Pc</i>AS and hepatic mRNA expression levels of 20 different cytokines and other inflammatory mediators were determined at different time points after infection (6, 8 and 10 days) by quantitative RT-PCR and normalized to 18S ribosomal RNA levels. In this figure, data are shown for iNOS (A), IL-1β (B), MHC class II (C), TGF-β (D), IP-10 (E) and TNF (F), the data of the other mediators are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113519#pone-0113519-t001" target="_blank">table 1</a>. Data are from two separate experiments. Each dot represents the result from an individual mouse. Horizontal bars between individual data points represent group medians and horizontal lines with asterisks on top indicate statistical differences between groups. Asterisks above individual data sets indicate statistical differences with the uninfected control group: * <i>p</i><0.05, ** <i>p</i><0.01 and *** <i>p</i><0.001.