Inflammatory cell recruitment to the liver.

<p>C57BL/6J mice were left uninfected (Con) or were infected with <i>Pb</i>ANKA, <i>Pb</i>NK65 or <i>Pc</i>AS and hepatic leukocytes were analyzed 8 (<i>Pb</i>ANKA) or 10 (<i>Pb</i>NK65, <i>Pc</i>AS) days after infection by flow cytometry. (A) Total numbers of monocytes/macrophages (F4/80⁺CD11b⁺), neutrophils (F4/80⁻CD11b⁺Gr-1⁺), CD4⁺ T cells and CD8⁺ T cells in the liver. Proportion of CD8⁺ T cells (B) or CD4⁺ T cells (C) expressing the early activation marker CD69. Proportion of monocytes/macrophages expressing CD80 (D) or MHC class II (E). Data are pooled from three separate experiments with similar results. (F) Histogram showing the MHC-II expression on F4/80⁺CD11b⁺ cells from Con, <i>Pb</i>ANKA, <i>Pb</i>NK65 or <i>Pc</i>AS-infected mice. (G) Spearman correlations between hepatic hemozoin (Hz) amounts and the proportion of monocytes/macrophages expressing MHC class II in infected mice. Spearman r and <i>p</i>-values are indicated.