EGb761 decreased BBB permeability in Aβ₁_–42 oligomer-induced bEnd.3 cells.

<p>BBB permeability, evaluated by the Na-F leakage test, was assessed after incubation with 10 µM Aβ_1–42 oligomer. Cells were incubated with or without various concentrations of EGb761 for 2 h, followed by incubation with Aβ_1–42 oligomer for 24 h. Then, the absorbance of Na-F was determined by fluorescence spectrophotometry. Results are shown as the Mean±S.E.M. (*<i>p</i><0.01, Aβ versus Control; #<i>p</i><0.01, EGb761+Aβ versus Aβ).