Interactions of high sPD-1 with high HBV viral load and copresence of these two risk factors with genotype C HBV in risks for HCC and liver cirrhosis.

a<p>ORs and 95% CIs were mutually adjusted for age (continuous variable), cigarette smoking (yes or no), alcohol consumption (yes or no), first-degree family history of HCC (yes or no), and BMI (≥25 or <25 kg/m²).</p>b<p>84 subjects with missing data on ultrasonography measurement of liver during follow-up were excluded from analysis.</p>c<p>33 subjects (2 HCC cases and 31 non-HCC subjects) with missing data on HBV genotype were excluded from analysis.</p>d<p>113 subjects were excluded due to missing data on follow-up ultrasonography measurement of liver and/or HBV genotype (80 were missing on follow-up ultrasonography measurement alone; 29 were missing on HBV genotype alone; 4 were missing on both variables).</p><p>AP, attributable proportion due to interaction; CI, confidence interval; HCC, hepatocellular carcinoma; LC, liver cirrhosis; OR, odds ratios; RERI, relative excess risk due to interaction.</p><p>Interactions of high sPD-1 with high HBV viral load and copresence of these two risk factors with genotype C HBV in risks for HCC and liver cirrhosis.