Time dependent effect of administration of D-473 (10 mg/kg, i.p) at time 0 (shown by arrow) on extracellular level of DA (Ο), 5-HT (▪), and NE (Δ); a) in rats Prefrontal cortex; and b) dorso lateral striatum.

<p>Results are expressed as percent baseline with baseline values all averaging 100%. Each point represents mean ± standard error (SE) of the percentage of baseline from five rats. Statistical analysis was performed by t-test analysis of every point relative to baseline values (i.e. 100%) using Prism 6 (Graphpad Software Inc, La Jolla, CA). * (DA) p<0.03-0.009; œ (NE) p<0.05- 0.01; # (5HT) p<0.05- 0.0001. P values <0.05 were considered to be statistically significant.