Effects of D-473 (PO) and GBR 12909 (i.p), on locomotor activity (horizontal activity, HACTV, measured by the number of infrared photobeam interuptions).

<p>D-473 was administered orally to the rats whereas Vehicle and GBR 12909 were injected i.p. The cumulative locomotor activities up to 90 min were measured. One way ANOVA analysis and subsequent Dunnett’s multiple comparisons testing demonstrates no significant difference between control and D-473 but a significant effect between control and GBR 12909: F (2,6) = 18.22 (P<0.0028). Asterisks indicate a statistically significant difference compared with Vehicle, **P<0.002. Each treatment group contains four to five rats.