FGFR1c mAb effects on energy expenditure and spontaneous locomotor activity.

<p>(A) Energy expenditure, spontaneous locomotor activity and (B) respiratory exchange ratio measured with a CLAMS open circuit indirect calorimetry system following a single injection with either R1c mAb or control mAb in female DIO mice (<i>n</i> = 7, 10 mg/kg i.p. indicated with an arrow). ***<i>P</i><0.001 <i>vs.</i> Control mAb, linear mixed model, N.S. = Non Significant. (C) Body weight change during the treatment period (42 h). **<i>P</i><0.01 <i>vs.</i> control mAb, Mann Whitney <i>U</i>-test. (D) mRNA expression in brown adipose tissue (BAT) and ovarian white adipose tissue (WAT) 4 d after a single injection of R1c mAb in female DIO mice fed <i>ad libitum</i> (<i>ad lib</i>) or control mAb treated female DIO mice fed <i>ad lib</i> or pair-fed (pf) twice daily to match the food intake in R1c mAb treated female DIO mice fed <i>ad lib</i> (<i>n</i> = 6, 3 mg/kg s.c.). *<i>P</i><0.05 <i>vs</i>. control mAb <i>ad lib</i> group; ^#<i>P</i><0.05 <i>vs</i>. control mAb pf group, Mann Whitney <i>U</i>-test. Values are means ± SEM.