Comparison of F-5 with becaplermin gel in promoting diabetic pig wound healing.

<p>(A) Images of 1.5 cm×1.5 cm full thickness wounds in triplicates in pigs 45 days following STZ injection were topically treated with increasing amounts of recombinant F-5 protein once on day 0. Wound closure was measured on day 7 and day 14. (B) Quantitative analysis of the wound closure data revealed an optimal concentration for F-5 between 30 µM to 45 µM. * <i>p</i>≤0.05 and ** <i>p</i>≤0.01, compared with placebo. (C) Images of similar wounds were topically treated with 45 µM of F-5 protein or becaplermin gel as prescribed in triplicate on day 0. Wound closure was compared on day 7 and day 14. (D) Quantitative analysis of F-5- and becaplermin gel- stimulated wound closure data. * <i>p</i>≤0.05, <i>p</i>≤0.01 and *** <i>p</i>≤0.001, compared with placebo.