Duration of diabetic conditions correlated with the length of delay in wound healing.

<p>The length (days) of delay in wound healing was examined in pigs injected with STZ for 20, 45 and 90 days prior to wound surgery. (A) Images of the 1.5 cm×1.5 cm full thickness wounds made in a representative normal pig; (B) Images of the wound healing in a representative pig 20 days after STZ injection; (C) Images of wounds in a representative pig 45 days after STZ injection; (D) Images of wounds in a representative pig 90 days after STZ injection; (E to G) Quantitative analyses of the wound healing data shown in B, C and D (n≥3) in comparison to wounds shown in A. * <i>p</i>≤0.05, ** <i>p</i>≤0.01 and *** <i>p</i>≤0.001, compared with placebo.