Progressively deteriorating ERG in R6/2 mice (in red) compared to their wild-type littermates (in blue).

<p>The uppermost rows represent the averaged ERG responses recorded at three different ages. Note that also wild-type responses change until animals reach a mature age. Solid lines represent a-wave statistics (mean±SEM) and dashed lines b-wave statistics in amplitude and latency graphs. B/a ratios presented on the lowest rows were calculated by dividing b-wave amplitudes by corresponding a-wave amplitudes. Statistically significant differences from t-test, or U-test in cases of unequal variances, are marked as *p<0.05; **p<0.01; ***p<0.001.