Overview on proteome changes of circulating extracellular vesicles in diet-induced NASH or control mice.

<p>(<b>A</b>) Venn diagrams depicting the total number of proteins and the number of proteins involved in cell death, stress and angiogenesis in EVs isolated from CDAA, CSAA or chow fed mice. (<b>B</b>) Heatmap and dendrogram based on log2 of normalized spectral counts for proteins elevated in EVs isolated from CDAA (n = 3, CD) compared to CSAA (n = 3, CS). Protein expression levels are color coded, showing a stronger and lower expression in green and red, respectively. Functional and molecular grouping of proteins identified in EVs isolated from CDAA-fed mice for 20 weeks. By using annotations derived from the Gene Ontology database, proteins have been organized based on (<b>C</b>) molecular function and (<b>D</b>) biological process.