Chromosome 10 controls both IFNγ production and MCMV resistance.

<p>(A, B) Freshly isolated splenocytes from B6, Css10 and BcA9 mice were stimulated with P/I for 4 h. The plots are gaited (A) on CD3⁻DX5⁺ NK cells (B) CD3⁺DX5⁻ T cells and the percentage of cells expressing intracellular IFNγ is shown. (C) Splenocytes from indicated strains were incubated for 4 h with RMAS-m157 and the percentage of Ly49H⁺ NK cells expressing intracellular IFNγ is shown. Data were analyzed using one way ANOVA with Bonferoni post-test and presented as mean ± SEM. **<i>P</i><0.01, ***<i>P</i><0.001. (D) Indicated mice were infected with MCMV and viral load was quantified from the spleen at day 3 p.i. Data were analyzed using two-tailed Student's <i>t</i>-test and presented as mean ± SEM. ***<i>P</i><0.001. Similar results were obtained in another independent experiment.