Sequence variation around differentially methylated CpGs.
- Michelle D. Johnson (669638)
- Michael Mueller (669639)
- Martyna Adamowicz-Brice (669640)
- Melissa J. Collins (669641)
- Pascal Gellert (145710)
- Klio Maratou (257446)
- Prashant K. Srivastava (669642)
- Maxime Rotival (133720)
- Shahena Butt (669643)
- Laurence Game (47015)
- Santosh S. Atanur (669644)
- Nicholas Silver (669645)
- Penny J. Norsworthy (669646)
- Sarah R. Langley (204186)
- Enrico Petretto (204195)
- Michal Pravenec (250703)
- Timothy J. Aitman (250706)
Publication date
December 2014
DOIAbstract
<p>(A) Plot showing the frequency of CpGs with a SNP within 1 kb for all CpG dinucleotides in the genome (red), all CpGs tested for differential methylation (blue), CpGs that showed a significant difference in methylation between BN and SHR rats (green), and differentially methylated CpGs with a CpG-disrupting SNP in the vicinity (purple). In the latter case the distance relates to the nearest CpG-disrupting SNP. (B) same plot as (A) zoomed in to the 10 bp interval around the CpG. (C) Sequence logos showing SNP allele frequencies around differentially methylated CpGs for alleles associated with increased (top) and decreased (bottom) methylation.</p
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