Effect of rapamycin on kidney glomerular morphology in NONcNZO10 mice.

<p>Untreated mice (A) show hyaline deposits, likely subendothelial, in the glomerular tuft. These deposits are greatly reduced in rapa-treated mice (B). The deposits are strongly positive for IgG in untreated mice (C), and IgG staining is greatly reduced in rapa-treated mice (D). 100 glomeruli from each mouse were scored for presence of nephritis (E) and/or hyaline thrombi deposits (F), showing quantitatively the reduction in kidney disease by rapa treatment.