Morphometry of lung granulomas and analysis of fungal burden in infected animals treated with rPCN.

<p>Each group of mice was either not treated (PBS) or therapeutically treated according to protocols G1–G4 (see <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003317#s2" target="_blank">Material and Methods</a>). Panel A: Number of granulomas per mm² of tissue. Panel B: Granuloma area, in µm². Panel C: Pulmonary CFU recovery. For morphometric analysis, the Image J program, developed by Wayne Rasband of the National Institute of Mental Health, was used. Bars depict the mean and SD. * p<0.05; ** p<0.01; *** p<0.001 <i>vs.</i> the PBS group.