Possible mechanism of the protection against murine paracoccidioidomycosis conferred by paracoccin administration, as suggested by <i>in vivo</i> and <i>in vitro</i> studies.

<p>Once administered to BALB/c mice, before or after inoculation of <i>P. brasiliensis</i> yeasts, rPCN interacts with N-glycans of TLRs on antigen-presenting cells (APC). It triggers IL-12 production, which drives immunity to the Th1 axis. Production of IL-10 is also induced. The consequent balanced Th1 immunity that is developed protects mice against PCM, as manifested by lower incidence of granulomatous lesions and more efficient fungal clearance in the lungs, at day 30 post-infection.