<p>For each sequence-structure map I calculate the probability of finding, among non-degenerate sequences, a genotype that folds onto a phenotype with designability C or larger. Here, designability is defined as the number of sequences per neutral set: C = (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003946#s2" target="_blank"><i>Models</i></a>). Color codes according <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003946#pcbi-1003946-g003" target="_blank">Fig. 3</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003946#pcbi-1003946-t001" target="_blank">Table 1</a>. Dashed black line, HP potential.</p
<div><p>Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fu...
We distinguish three patterns of architectures with increasing genomic background mutation rate Θbg:...
This paper examines the implicit maintenance of diversity within a population through the inclusion ...
<p>For each sequence-structure map , generated by potential , plots present the expected size of seq...
Among the most fundamental features shared by all organisms is the mapping of information encoded in...
The evolutionary dynamics of molecular populations are strongly dependent on the structure of genoty...
<p>(A) Number of genotype components versus the expected size of neutral sets. (B) Number of neutral...
<p>(a), (b) The more robust phenotype has higher structural diversity in its 1-neighbourhood. We obs...
Genotypes are viable or lethal independently with probability p. The sequence length is L = 10. (PDF...
Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to s...
<p>Phenotypes are represented by colours, genotypes as nodes and mutations as edges. A) Each colour ...
The map between genotype and phenotype is fundamental to biology. Biological information is stored a...
Genotype–phenotype relations are usually inferred from a deterministic point of view. For example, q...
Large sets of genotypes give rise to the same phenotype because phenotypic expressionis highly redun...
<p>Predictions from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.00201...
<div><p>Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fu...
We distinguish three patterns of architectures with increasing genomic background mutation rate Θbg:...
This paper examines the implicit maintenance of diversity within a population through the inclusion ...
<p>For each sequence-structure map , generated by potential , plots present the expected size of seq...
Among the most fundamental features shared by all organisms is the mapping of information encoded in...
The evolutionary dynamics of molecular populations are strongly dependent on the structure of genoty...
<p>(A) Number of genotype components versus the expected size of neutral sets. (B) Number of neutral...
<p>(a), (b) The more robust phenotype has higher structural diversity in its 1-neighbourhood. We obs...
Genotypes are viable or lethal independently with probability p. The sequence length is L = 10. (PDF...
Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to s...
<p>Phenotypes are represented by colours, genotypes as nodes and mutations as edges. A) Each colour ...
The map between genotype and phenotype is fundamental to biology. Biological information is stored a...
Genotype–phenotype relations are usually inferred from a deterministic point of view. For example, q...
Large sets of genotypes give rise to the same phenotype because phenotypic expressionis highly redun...
<p>Predictions from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.00201...
<div><p>Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fu...
We distinguish three patterns of architectures with increasing genomic background mutation rate Θbg:...
This paper examines the implicit maintenance of diversity within a population through the inclusion ...