<p>Time series for single SD excursions in (<b>a</b>), (<b>c</b>) the reduced and in (<b>b</b>), (<b>d</b>) the detailed model. In the reduced model SD is triggered by an interruption of the pump activity for about 10 sec (shaded region). In the detailed model the extracellular potassium concentration is increased by mM after 20 sec (vertical line). In (<b>a</b>) and (<b>b</b>) the time series of the membrane potentials (black lines) are shown. Nernst potentials for all ion species are included to the diagrams as a reference. Ion dynamics are shown in (<b>c</b>) and (<b>d</b>) where extracellular ion concentrations are in lighter color.</p
ABSTRACT Intracellular effects of submicrosecond, megavolt-per-meter pulses imply changes in a cell’...
<p>The values of parameters , and are same as in Fig. 2. (a)(b) = 0.3, = 0.9; (c)(d) = 0.5, = ...
AbstractUnder many different conditions activated plasma membrane ion channels give rise to changes ...
<p>(<b>a</b>) Response of the model to a sec long sodium current pulse with amplitude 150 (marked ...
<p>(<b>A</b>) The nominal depolarization (top plot), the intracellular sodium (red line) and extrace...
<p>SD is initiated by interrupting pump activity and glial ion regulation for 20 sec (shaded or hatc...
<p>In the left panel the membrane dynamics are shown that occur after the onset of OGD (solid line)....
<p>Time-dependent changes in the membrane potential (<b>A</b>), intracellular concentration (<b>B<...
<p>Bifurcation diagram of the reduced model for as the bifurcation parameter (purely transmembrane ...
<p>Fundamental bifurcation diagram in the slowest–scale dynamics, the potassium ion gain or loss thr...
Blue lines represent the results of this work with inclusion of [K+]i dynamics, green lines represen...
<p>(A,C) The Ex293 membrane model replicates (dotted line) the experimentally observed peak current-...
<p>(<b>a</b>) Stimulation with the same, but earlier applied, current pulse as in <a href="http://ww...
The myocardial ischemic border zone is associated with the initiation and sustenance of arrhythmias....
<p>(<b><i>A</i></b>) The traces depict a sigmoidal reduction of G<sub>max,Kir</sub> from 0.2 nS to 0...
ABSTRACT Intracellular effects of submicrosecond, megavolt-per-meter pulses imply changes in a cell’...
<p>The values of parameters , and are same as in Fig. 2. (a)(b) = 0.3, = 0.9; (c)(d) = 0.5, = ...
AbstractUnder many different conditions activated plasma membrane ion channels give rise to changes ...
<p>(<b>a</b>) Response of the model to a sec long sodium current pulse with amplitude 150 (marked ...
<p>(<b>A</b>) The nominal depolarization (top plot), the intracellular sodium (red line) and extrace...
<p>SD is initiated by interrupting pump activity and glial ion regulation for 20 sec (shaded or hatc...
<p>In the left panel the membrane dynamics are shown that occur after the onset of OGD (solid line)....
<p>Time-dependent changes in the membrane potential (<b>A</b>), intracellular concentration (<b>B<...
<p>Bifurcation diagram of the reduced model for as the bifurcation parameter (purely transmembrane ...
<p>Fundamental bifurcation diagram in the slowest–scale dynamics, the potassium ion gain or loss thr...
Blue lines represent the results of this work with inclusion of [K+]i dynamics, green lines represen...
<p>(A,C) The Ex293 membrane model replicates (dotted line) the experimentally observed peak current-...
<p>(<b>a</b>) Stimulation with the same, but earlier applied, current pulse as in <a href="http://ww...
The myocardial ischemic border zone is associated with the initiation and sustenance of arrhythmias....
<p>(<b><i>A</i></b>) The traces depict a sigmoidal reduction of G<sub>max,Kir</sub> from 0.2 nS to 0...
ABSTRACT Intracellular effects of submicrosecond, megavolt-per-meter pulses imply changes in a cell’...
<p>The values of parameters , and are same as in Fig. 2. (a)(b) = 0.3, = 0.9; (c)(d) = 0.5, = ...
AbstractUnder many different conditions activated plasma membrane ion channels give rise to changes ...