Modeling biophysical manipulations.

<p><b>A.</b> Synaptic connection strength is varied. Sub plots from left to right: speed of wave front at rest (when ) as a function of conductance , velocity indicates maximum wave-front speed since and is monotonically decreasing, point at which becomes zero represents excitability threshold; wave-front speed as function of refractory variable for three different values of ; from 5000 s of simulation of model with indicated values of interwave-inteval; wave speed distribution; and mean wave size. <b>B.</b> Sub plots from left to right: dynamics of refractory variable of individual SAC following depolarization with different sAHP timescales , black line indicates refractory value above which and thus represents an absolute refractory time period in which SAC is not sufficiently excitable to participate in future wave activity; from 5000 s of simulation of model with indicated values of inter-wave interval; wave speed distribution; and mean wave size.