Biomarker correlation plots A: SPC and GlcSph.

<p>The control subjects are black circles, the NP-C patients are colored by miglustat treatment status as for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114669#pone-0114669-g003" target="_blank">Figure 3E</a>. A Spearman correlation analysis gave (r, p value) for control (0.48, <0.0001), NP-C miglustat naïve (−0.11, 0.63), NP-C miglustat treated (0.75, <0.0001) and miglustat unknown (0.28, 0.46). The dotted horizontal and vertical lines are the 95% percentile of the entire control group for SPC (10.3 nM) and GlcSph (2.4 nM) respectively. <b>B: SPC and cholestan-3β,5α,6β-triol.</b> For controls (black circles) and NP-C (red squares). The 2 markers did not correlate for the NP-C patients (Spearman r = 0.265, p = 0.273). The horizontal dotted line represents the 95 percentile of normal for cholestan-3β,5α,6β-triol (0.04 ng/µL). The vertical cut-off is 95 percentile of normal for SPC. Values below the assay LOQ were set at the LOQ for SPC (5 nM) and cholestan-3β,5α,6β-triol (0.001 ng/uL).