Interactome of X-linked disease risk genes.

<p>All 22 X-linked protein-coding genes that showed evidence of association and replication (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113684#pone-0113684-g001" target="_blank">Figure 1</a>) are denoted by black diamonds and are presented together with genes that interact with them (grey circles) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113684#s3" target="_blank">Materials and Methods</a>). <i>Physical interactions</i> refer to documented protein-protein interactions. <i>Genetic interactions</i> represent genes where perturbations to one gene affect another. <i>Predicted interactions</i> were obtained from orthology to interactions present in other organisms <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113684#pone.0113684-WardeFarley1" target="_blank">[159]</a>. All but four of these 22 genes share interacting partners according to these known and predicted interactions. Results of a pathway analysis based on this interactome are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113684#pone-0113684-t005" target="_blank">Table 5</a>.