Antibody response to immunization with IB010.

<p>Serum samples were collected from ATCC 19606 vaccinated, IB010 vaccinated and control mice before vaccination (Day 0) and at day 7 and 21 after the first immunization, and levels of antigen specific total IgG (A) and IgM (B) were measured by ELISA (n = 8 mice/group). IgG1 (C) and IgG2c (D) levels in serum collected 7 days after the second immunization were determined in serum were measured by ELISA in ATCC 19606 vaccinated, IB010 vaccinated and control mice In all panels box and whisker plots represent the interquartile ranges and ranges, respectively, and horizontal lines represent median values. * p<0.05 compared to levels in control mice at the same time point, # p<0.05 compared to 7-day samples from the same experimental group, † p<0.05 compared to 21-day samples in ATCC 19606 vaccinated mice.