<p>The simulation setting is similar to that described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114523#pone-0114523-t001" target="_blank">Table 1</a>, model 5, but with different risk allele frequency (RAF) with n = 5000 cases/controls, and OR<sub>g</sub> = 2. Number of simulations is 200 for each setting.</p
International audienceObjective: Assessing the statistical power to detect susceptibility variants p...
International audienceObjective: Assessing the statistical power to detect susceptibility variants p...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...
<p>The simulation setting is described in <a href="http://www.plosone.org/article/info:doi/10.1371/j...
<p>The simulation setting is described in <a href="http://www.plosone.org/article/info:doi/10.1371/j...
<p>The relative genotype risks are . <i>K</i> represents disease prevalence and <i>p</i> is the freq...
<p>Before carrying out these steps, a large pool of haplotypes (<i>n</i> = 15,000) was simulated. Gi...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>The relative genotype risks are . <i>K</i> represents disease prevalence and <i>p</i> is the freq...
<p>The relative genotype risks are . <i>K</i> represents disease prevalence and <i>p</i> is the freq...
<p>In scenario I, only phenotype 1 is associated with the SNP. <i>rG</i> = 1 or −1 does not affect t...
<p>*. The simulation model consists of 5 covariates, each with OR of 1.5. In analysis, we assume tha...
<p>An example of simulated data showing a subset of haplotypes with a peak in the number of derived ...
<p>Left panel: Power versus relative risk ratio (RRR) for different sample sizes, minor allele frequ...
<p>OR is tabulated for each genotype of causal SNPs as in Namkung <i>et al.</i><a href="http://www.p...
International audienceObjective: Assessing the statistical power to detect susceptibility variants p...
International audienceObjective: Assessing the statistical power to detect susceptibility variants p...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...
<p>The simulation setting is described in <a href="http://www.plosone.org/article/info:doi/10.1371/j...
<p>The simulation setting is described in <a href="http://www.plosone.org/article/info:doi/10.1371/j...
<p>The relative genotype risks are . <i>K</i> represents disease prevalence and <i>p</i> is the freq...
<p>Before carrying out these steps, a large pool of haplotypes (<i>n</i> = 15,000) was simulated. Gi...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>The relative genotype risks are . <i>K</i> represents disease prevalence and <i>p</i> is the freq...
<p>The relative genotype risks are . <i>K</i> represents disease prevalence and <i>p</i> is the freq...
<p>In scenario I, only phenotype 1 is associated with the SNP. <i>rG</i> = 1 or −1 does not affect t...
<p>*. The simulation model consists of 5 covariates, each with OR of 1.5. In analysis, we assume tha...
<p>An example of simulated data showing a subset of haplotypes with a peak in the number of derived ...
<p>Left panel: Power versus relative risk ratio (RRR) for different sample sizes, minor allele frequ...
<p>OR is tabulated for each genotype of causal SNPs as in Namkung <i>et al.</i><a href="http://www.p...
International audienceObjective: Assessing the statistical power to detect susceptibility variants p...
International audienceObjective: Assessing the statistical power to detect susceptibility variants p...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...