<p>*A pairwise sequence alignment of AURKA_HUMAN against the individual kinases was done with blast-p to calculate the sequence identity.</p><p>Sequence identity of kinases bound by multi-targeted AK inhibitors with AK.</p
Abstract Background Phosphorylation events direct the flow of signals and metabolites along cellular...
The central role of kinases in virtually all signal transduction networks is the driving motivation ...
The key residues involved in drug/target interactions (shown bottom) are highlighted by arrows in st...
<p>A pairwise sequence alignment of the AK sequence (AURKA_HUMAN) against the annotated kinome prese...
Pachl F, Plattner P, Ruprecht B, Medard G, Sewald N, Kuster B. Characterization of a Chemical Affini...
Motivation: Most of the protein tyrosine kinases found in bacteria have been recently classified in ...
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been li...
In human there are 518 protein kinases reported and many of them are involved in several cellular pr...
<p>Depicted is a schematic of the work flow followed to achieve a master alignment of all known kina...
Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease. Kinas...
The central role of kinases in virtually all signal transduction networks is the driving motivation ...
<p>(<b>A</b>) Alignment of the amino acid sequence of the N-terminal kinase domain of ArSLK with tho...
<p>Canonical domain architectures of classified subfamily and source subfamily are shown. Sequence i...
The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has ...
Hagenstein M, Mußgnug J, Kruse O, Sewald N. Affinity-based tagging of kinases with reversible inhibi...
Abstract Background Phosphorylation events direct the flow of signals and metabolites along cellular...
The central role of kinases in virtually all signal transduction networks is the driving motivation ...
The key residues involved in drug/target interactions (shown bottom) are highlighted by arrows in st...
<p>A pairwise sequence alignment of the AK sequence (AURKA_HUMAN) against the annotated kinome prese...
Pachl F, Plattner P, Ruprecht B, Medard G, Sewald N, Kuster B. Characterization of a Chemical Affini...
Motivation: Most of the protein tyrosine kinases found in bacteria have been recently classified in ...
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been li...
In human there are 518 protein kinases reported and many of them are involved in several cellular pr...
<p>Depicted is a schematic of the work flow followed to achieve a master alignment of all known kina...
Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease. Kinas...
The central role of kinases in virtually all signal transduction networks is the driving motivation ...
<p>(<b>A</b>) Alignment of the amino acid sequence of the N-terminal kinase domain of ArSLK with tho...
<p>Canonical domain architectures of classified subfamily and source subfamily are shown. Sequence i...
The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has ...
Hagenstein M, Mußgnug J, Kruse O, Sewald N. Affinity-based tagging of kinases with reversible inhibi...
Abstract Background Phosphorylation events direct the flow of signals and metabolites along cellular...
The central role of kinases in virtually all signal transduction networks is the driving motivation ...
The key residues involved in drug/target interactions (shown bottom) are highlighted by arrows in st...
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