MSA of the kinase domains of AK and other sequentially similar kinases obtained from kinbase.

<p>A pairwise sequence alignment of the AK sequence (AURKA_HUMAN) against the annotated kinome present in Kinbase v1.1 was done using blast-p (Table S3 in File S2). The kinase domains of the sequentially similar sequences were retrieved from Kinbase v1.1 and a MSA was constructed with ClustalW 2.1. Jalview 2.8.0 has been used to view the alignment and the colour scheme is as per ClustalX. The red dots represent kinases which have been crystallized with different AK inhibitors (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113773#pone-0113773-t002" target="_blank">Table 2</a>). The labelled residues indicate the possible sites for target specific inhibitor binding in AK based on conservation.