The OB-BMST and Core OB-BMST contain genes from stem cell niche signatures.

<p>Venn diagrams showing the number of overlapping OB-BMST (<b>A</b> and <b>B</b>) and Core OB-BMST (<b>C</b> and <b>D</b>) genes with gene signatures derived from the hematopoietic (<b>A</b> and <b>C</b>) and the developing prostate (<b>B</b> and <b>D</b>) stem cell niches. Relative expression levels of <i>Ptn</i>, <i>Epha3</i>, <i>Cd109</i> and <i>Slit3</i>. <b>E.</b> VCaP (grey, <i>n</i> = 3) and C4-2B (black, <i>n</i> = 4) intra-osseous xenografts; values are shown as fold change (mean ± SD) relative to contralateral and sham-operated bones. <b>F.</b> VCaP (grey, <i>n</i> = 5) orthotopic xenografts; values are shown as fold change (mean ± SD) relative to intact and sham-operated prostate. <b>G.</b> VCaP (grey, <i>n</i> = 3) and C4-2B (black, <i>n</i> = 5) subcutaneous xenografts; values are shown as fold change (mean ± SD) relative to intact skin. <b>H.</b> PC-3 (light grey, <i>n</i> = 6) intra-osseous xenografts; values are shown as fold change (mean ± SD) relative to contralateral and sham-operated bones (<i>n</i> = 3–4). *, <i>P</i><0.01; **, <i>P</i><0.001; ***, <i>P</i><0.0001; ****, <i>P</i><0.0001. Abbreviations: HSCs, hematopoietic stem cells; UGM urogenital mesenchyme; <i>Ptn</i>, pleiotrophin; <i>Epha3</i>, Eph receptor a3; <i>Slit3</i>, slit homolog 3.