The recovery of ABR thresholds is associated with the level of pre-noise ABR thresholds in the Prestin-CreER^T2 homozygous mice.

<p><b>A</b> Comparison of ABR threshold shifts among the homozygous, heterozygous and WT mice examined at 7 d post-noise exposure. The homozygotes displays less threshold shifts as compared with the heterozygous and WT mice (two-way ANOVA, <i>F_2,116</i> = 16.77, <i>P</i><0.001). <b>B</b> Correction of the recovery proportion of ABR thresholds and the pre-noise ABR thresholds. The proportion of ABR recovery is increased with the increase in the level of pre-noise ABR thresholds (Pearson's correction analysis, <i>r</i> = 0.8; <i>p</i> = 0.0004). The results suggest that the functional status of OHCs before exposure to the noise affects the functional recovery of the cochleae after exposure to the noise. <b>C</b> Correction of the recovery of ABR thresholds and the acute threshold shifts examined at 2 h post the acoustic overstimulation. Notice that with the increase in the magnitude of threshold shifts, the proportion of ABR recovery is decreased (Pearson's correction analysis, <i>r</i> = −0.71; <i>p</i> = 0.0028).