Effects of <i>parkin</i> genetic deletion on hippocampal synaptic transmission and plasticity processes.

<p>(A) Input-output curve of field excitatory post-synaptic potentials (fEPSP, measured as their slope) recorded in Schaffer fibers-CA1 pyramid synapses of hippocampal slices from wild-type and <i>parkin</i>^−/− mice. (B) Paired pulse facilitation (PPF), measured as the ratio of fEPSPs' slope ratio between the second and first paired stimuli (P2/P1 ratio) with different interpulse intervals (25, 50, 100, 200 and 400 ms) recorded in hippocampal slices from wild-type and <i>parkin</i>^−/− mice. (C) Modification of fEPSPs' slope, presented as % of baseline, before and after θ-burst stimulation in slices from wild-type and <i>parkin</i>^−/− mice. (D) Potentiation of fEPSPs' slope after the θ-burst stimulation, presentage as % increase of baseline fEPSPs' slope, in slices from wild-type and <i>parkin</i>^−/− mice <i>*P</i><0.05 compared to wild-type control group. Data are mean ± s.e.m. of n = 4 per group.