<p>Ets and GATA binding sites are indicated with a circle and square, respectively. Mutated sites are indicated with closed circles and squares. The mutations introduced into the binding sites (underlined) are in lowercase. Each bar represents the mean ±SEM from three independent experiments performed in triplicate [***<i>p</i><0.001 vs. pGL4.10-<i>ckβ</i>(−2000/−1)].</p
<p>(A) Luciferase assay. The Ets-2 binding sites (GGGAAG) were replaced with <i>Hind</i>III sites (A...
<p><b>(</b>A) Schematic diagram representing wild-type and the mutant promoter constructs. Mutations...
<p>(A) A schematic representation of GATA-REs (Wt) and their mutants (M1, M2 and M3 for CAT assay; m...
<p>(A) EMSA was performed by using biotinylated <i>ckβ</i>-Ets/GATA probes with or without mutations...
<p><b>A.</b> Diagram of the promoter region of <i>STM2209-STM2208</i>, showing GATC sites (red squar...
<p>Quantitative analysis of GATA4 proteins binding to wtNKX2-5-FLAG. The effect of GATA4 mutations o...
<p>(A) Schematic representation of the probes used in EMSA studies. (B) GATA4 binding to rBNP -90 ta...
<p>Recombinant GATA3 and NFAT1 were used to characterize binding. Mutated CRTh2 proximal oligonucleo...
<p>A. A schematic of the overlapping EBox/GATA (GATA/EBoxwt) binding sites at −495 and −486 base pai...
<p>The -699bp ANP promoter was utilized to study the transcriptional activity of the GATA4 mutants o...
<p>A, Schematic representation of the 5′upstream region of the DKK2 gene. The nucleotide numbering r...
<p>(A) Results using the rat BNP minimal promoter and (B) the rat BNP promoter with the -90 tandem G...
<p>(A–C) Promoter activation by GATA and Nur77 was studied in NCI-R cells transiently transfected wi...
The human glycoprotein IIB (GPIIB) gene is expressed only in megakaryocytes, and its promoter displa...
<p>The sequence of the human <i>Tal2</i> P2-promoter is shown and identified potential transcription...
<p>(A) Luciferase assay. The Ets-2 binding sites (GGGAAG) were replaced with <i>Hind</i>III sites (A...
<p><b>(</b>A) Schematic diagram representing wild-type and the mutant promoter constructs. Mutations...
<p>(A) A schematic representation of GATA-REs (Wt) and their mutants (M1, M2 and M3 for CAT assay; m...
<p>(A) EMSA was performed by using biotinylated <i>ckβ</i>-Ets/GATA probes with or without mutations...
<p><b>A.</b> Diagram of the promoter region of <i>STM2209-STM2208</i>, showing GATC sites (red squar...
<p>Quantitative analysis of GATA4 proteins binding to wtNKX2-5-FLAG. The effect of GATA4 mutations o...
<p>(A) Schematic representation of the probes used in EMSA studies. (B) GATA4 binding to rBNP -90 ta...
<p>Recombinant GATA3 and NFAT1 were used to characterize binding. Mutated CRTh2 proximal oligonucleo...
<p>A. A schematic of the overlapping EBox/GATA (GATA/EBoxwt) binding sites at −495 and −486 base pai...
<p>The -699bp ANP promoter was utilized to study the transcriptional activity of the GATA4 mutants o...
<p>A, Schematic representation of the 5′upstream region of the DKK2 gene. The nucleotide numbering r...
<p>(A) Results using the rat BNP minimal promoter and (B) the rat BNP promoter with the -90 tandem G...
<p>(A–C) Promoter activation by GATA and Nur77 was studied in NCI-R cells transiently transfected wi...
The human glycoprotein IIB (GPIIB) gene is expressed only in megakaryocytes, and its promoter displa...
<p>The sequence of the human <i>Tal2</i> P2-promoter is shown and identified potential transcription...
<p>(A) Luciferase assay. The Ets-2 binding sites (GGGAAG) were replaced with <i>Hind</i>III sites (A...
<p><b>(</b>A) Schematic diagram representing wild-type and the mutant promoter constructs. Mutations...
<p>(A) A schematic representation of GATA-REs (Wt) and their mutants (M1, M2 and M3 for CAT assay; m...