Cross-sectional associations of BMI with systemic metabolites across four cohorts of adolescents and young adults, and consistency in two populations of older individuals.

<p>Association magnitudes are in units of 1-SD metabolite concentration per 1-kg/m² increment in BMI. Color coding indicates the respective cohorts. White dots indicate β-regression coefficients, colored shading indicates 95% confidence intervals, and darker shading denotes <i>p</i><0.0005. The associations were analyzed for men and women combined and adjusted for sex and age, as well as smoking status, alcohol intake, and physical activity index. MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; SHBG, sex hormone–binding globulin.