Relative codon translational accuracy shifts coherently across the drosophilid phylogeny.

<p>(A) Overview of Akashi selection scores, the average population-scaled fitness difference between a synonymous codon change at a conserved amino acid site compared to the same change at variable site within the same gene. Selection scores are symmetric, such that score(codon X to codon Y) = −score(Y to X). All possible synonymous codon-to-codon pairs are shown, with the order of X and Y chosen such that the <i>D. melanogaster</i> values are positive. (B) Akashi selection scores for all 2-fold-degenerate C/U-ending codons. Error bars indicate 95% confidence intervals.