<p>The specificity of nicotine binding to antisera collected from TCCnic-12 immunized mice was determined by competitive ELISA for nicotine, cotinine and acetylcholine. IC<sub>50</sub> values for cotinine were 1000-fold greater than nicotine and could not be calculated for acetylcholine due to a lack of inhibition.</p
International audienceNicotinic acetylcholine receptors play important roles in numerous cognitive p...
Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assist...
<p>Immunogen doses are the total administered, i.e. 100 µg bivalent = 50 µg 3′-AmNic-rEPA and 50 µg ...
<p>Panel A: BALB/c mice (n = 12/gp) were immunized by IM injection with 10 µg of different nicotine ...
<p>C57BL/6 mice (5/grp) were injected (d0, d14, d146) with either PBS or 2.5 µg of the indicated con...
<div><p>Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodi...
Vaccination against nicotine is being studied as a potential treat-ment for nicotine dependence. Som...
<p>C57BL/6 mice (5/grp) were injected (d0, d14, d146) with either PBS or 2.5 ug of the indicated con...
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) ...
<p>Plasma was collected on day 56 and pooled from mice immunized on days 0, 21 and 42 to determine n...
<p>C57BL/6 mice (5/grp) were immunized (d0, d14, d146) with either PBS or 2.5 µg of the indicated co...
We describe an 1251-based RIA for cotinine, the major metabollte of nicotine. The slope of the dose-...
<p>Kd values (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114366#pone-011...
Vaccination against nicotine blocks or attenuates nicotine-re-lated behaviors relevant to addiction ...
<p>Serum was collected 56 days after priming from mice immunized with: (1) 10 µg (-) 1’ P9, (2) 10 µ...
International audienceNicotinic acetylcholine receptors play important roles in numerous cognitive p...
Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assist...
<p>Immunogen doses are the total administered, i.e. 100 µg bivalent = 50 µg 3′-AmNic-rEPA and 50 µg ...
<p>Panel A: BALB/c mice (n = 12/gp) were immunized by IM injection with 10 µg of different nicotine ...
<p>C57BL/6 mice (5/grp) were injected (d0, d14, d146) with either PBS or 2.5 µg of the indicated con...
<div><p>Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodi...
Vaccination against nicotine is being studied as a potential treat-ment for nicotine dependence. Som...
<p>C57BL/6 mice (5/grp) were injected (d0, d14, d146) with either PBS or 2.5 ug of the indicated con...
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) ...
<p>Plasma was collected on day 56 and pooled from mice immunized on days 0, 21 and 42 to determine n...
<p>C57BL/6 mice (5/grp) were immunized (d0, d14, d146) with either PBS or 2.5 µg of the indicated co...
We describe an 1251-based RIA for cotinine, the major metabollte of nicotine. The slope of the dose-...
<p>Kd values (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114366#pone-011...
Vaccination against nicotine blocks or attenuates nicotine-re-lated behaviors relevant to addiction ...
<p>Serum was collected 56 days after priming from mice immunized with: (1) 10 µg (-) 1’ P9, (2) 10 µ...
International audienceNicotinic acetylcholine receptors play important roles in numerous cognitive p...
Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assist...
<p>Immunogen doses are the total administered, i.e. 100 µg bivalent = 50 µg 3′-AmNic-rEPA and 50 µg ...
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