Depiction and distance analysis of associations between genotype and DNA methylation of significant mQTLs in human pancreatic islets.

<p>Depiction of (<b>A</b>) the most significant <i>cis</i>-mQTL; rs1771445 vs. cg02372404, and (<b>B</b>) the least significant <i>cis</i>-mQTL; rs196489 vs. cg06433283, among all identified <i>cis</i>-mQTLs in human pancreatic islets. Data is presented as Box and Whisker plots with P-values adjusted for multiple testing. (<b>C</b>) Distance analysis between SNPs and CpG sites of significant <i>cis</i>-mQTLs plotted as the number of identified mQTLs within each distance bin. Distance summary: minimum = 0 kb, 10%ile = 1.88 kb, 25%ile = 7.62 kb, 50%ile = 26.31 kb, 75%ile = 74.76 kb, 90%ile = 164.5 kb, maximum = 499.6 kb. (<b>D</b>) The strength of associations plotted against the distance between SNPs and CpG sites of significant <i>cis</i>-mQTLs after correction for multiple testing. Depiction of (<b>E</b>) the most significant <i>trans</i>-mQTL; rs17660464 vs. cg22968622, and (<b>F</b>) the least significant <i>trans</i>-mQTL; rs6440971 vs. cg10438649, among all identified <i>trans</i>-mQTLs in human pancreatic islets. Data is presented as Box and Whisker plots with P-values adjusted for multiple testing. (<b>G</b>) Quantile-Quantile plots (Q-Q plots) of –log10 (P-values) illustrating the distribution of P-values for all analyzed SNP-CpG pairs in the <i>cis</i>- (red dots) and <i>trans</i>- (blue dots) mQTL analysis in relation to a theoretical null distribution (grey diagonal line). Bold dots indicate significant mQTLs identified in the <i>cis</i>- (red dots) and <i>trans</i>-(blue dots) mQTL analysis after correction for multiple testing.