Identified genetic variants in folate metabolism genes in spina bifida patients and unaffected parents.

<p>*The P-values in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114903#pone-0114903-t001" target="_blank">Table 1</a> are generated by 10 000 random permutations of the input data scored according to the strength of association with the phenotype using DBDB recommendations (random reassignment of the scores to network nodes and computation of the corresponding randomized scores for all candidate genes) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114903#pone.0114903-Nitsch1" target="_blank">[38]</a>.</p><p>**Family 1: affected children 2C1, 2C2; mother 2M, father 2F. Family 2: affected children 6C1, 6C2; mother 6M, father 6F.</p><p>Identified genetic variants in folate metabolism genes in spina bifida patients and unaffected parents.