Panel A: Anti-CS titers in cases, controls and 19 protected children with low anti-CS antibodies titer and high malaria exposure index during 15 months of follow-up.

<p>Panel B: Matrix diagram showing correlation between antibody avidity measured at three time points during the follow up. Significant correlation observed between AI at 1 month post-dose 3 and at ∼8 months post-dose 3 (r = 0.33, p value = 0.0111) and at 1 month and 12 months post-dose 3 (r = 0.48, p value = 0.0002). Panel C: Correlation between anti-CS antibody avidity at 1 month post dose 3 and age (r = 0.003, p value = 0.656) Panel D: Correlation between anti-CS antibody avidity and anti-CS antibody titers at 1 month post dose 3 (r = –0.03; p value = 0.859).