Differential spectrum of tumor-specific variations are related with the transcriptional deregulation of the early and advanced HCC.

<p><b>A.</b> The barplot shows the average enrichment scores of the gene expressions in the GO terms in each patient. The enrichment scores of the gene sets are calculated as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115152#s2" target="_blank">Method</a>. The GO terms of the genes with mutations and the ones without mutations are indicated as mutated type (MT) and wild type (WT), respectively. <b>B.</b> The heatmap shows the differentially enriched functions of mutated genes with deregulated expression. The categories with similar functions are indicated as a barplot of different colors (<i>right bar</i>). <b>C.</b> Network view of the 48 mutated genes with differential expression between the early and advanced HCC subgroups. The <i>CTNNB1</i> gene harbored the largest interaction partners indicated with yellow color.