HSV-2 modulates the phenotype of migratory CD4⁺ T cells and CD3⁻ HLA-DR⁺ cells.

<p>A) The fold increases in the MFI of the α₄β₇^high CD4⁺ T cells (left) and the frequencies of CD62L⁺ (center) and CCR6⁺ (right) CD4⁺ T cells that migrated out of the HSV-2 infected mucosa 18 hours after infection are shown compared to the Acyclovir control (+ACV, set as 1; n = 13–19). B) The fold increases in the frequencies of α₄β₇^high CD80⁺ (left) CCR6⁺ (center) and CD103⁺ (right) CD3⁻ HLA-DR⁺ cells that migrated out of the HSV-2 infected mucosa 3 days after infection are shown compared to the Acyclovir control (+ACV, set as 1; n = 6–13). Bars represent mean ± SEM. Wilcoxon signed-rank test p values are shown. p<0.05 was considered significant.