Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii
- Hucheng Zhu (1576936)
- Chunmei Chen (1531813)
- Jing Yang (13969)
- Xiao-Nian Li (1261545)
- Junjun Liu (674159)
- Bin Sun (210373)
- Sheng-Xiong Huang (684901)
- Dongyan Li (1523254)
- Guangmin Yao (1523245)
- Zengwei Luo (1523248)
- Yan Li (23143)
- Jinwen Zhang (1523269)
- Yongbo Xue (1523251)
- Yonghui Zhang (279832)
Publication date
December 2014
DOIAbstract
Hyperisampsins A–D (<b>1</b>–<b>4</b>), with tetracyclo[6.3.1.1<sup>3,10</sup>.0<sup>3,7</sup>]tridecane skeletons and seven biogenetically related congeners (<b>5</b>–<b>11</b>), were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. The absolute configuration of <b>1</b> was established by ECD calculations, and those of <b>5</b> and <b>9</b> were confirmed by single X-ray crystallographic analyses. Hyperisampsins A and D showed potent anti-HIV activities with EC<sub>50</sub> of 2.97 and 0.97 μM and selectivity index of 4.80 and 7.70, respectively
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