The enhancement of tumor growth and lymph node metastasis in miR-518c transfectants.

<p>(A, B) B88-transfectants (A) and CAL27-transfectants (B) were orthotopically inoculated into the masseter muscle of nude mice, which were sacrificed at day 35. The size of primary tumors was measured once a week. The results presented are the means ± SD. *; p<0.05 when compared to mock cells by one-way ANOVA. (C) Representative H&E staining of the metastatic lymph nodes from the nude mice inoculated with B88-mock2 cells (left) and B88-518c cells (right). (D, E) The weight of the submandibular lymph nodes was measured in the mice inoculated with B88-transfectants (D) and CAL27-transfectants (E). *; p<0.05 when compared to mock cells by one-way ANOVA.