Fitness gain and number of potential oncogene changes when subjected to type I population bottleneck.

<p>Each boxplots represents median and standard deviation of maximal fitness gain before and after the bottleneck for 50 simulation repeats. The dots represent the percentage of potential oncogenes before and after passing through the bottleneck (see main text for definition). Gene expression noise level is 0, population size is indicated in color, and mutation rates are A) 0.001, B) 0.05, C) 0.1and D) 0.2.