MC13 phenotypes.

<p>Mutant embryos (B) are grossly distinguishable from wild-type littermates (A) by the shape of their heads and shortened, thickened limbs. (C–F) Skeletal preparations to highlight bones (red) and cartilage (blue) show the dramatic skeletal phenotypes in MC13 mutants (D,F). (G,H) Measurements of heads and limbs show significant shortening (G) and widening (H) of these elements in MC13 mutants (sample size indicated for each bone. *p<0.02, **p<0.006, ***p<0.0001).