Expression of Ror2 promotes <i>in vivo</i> tumor growth and invasion.

<p><b>A&C</b>) Tabulated rates of successful injection and growth of all 786-0 xenograft tumors are shown. <b>B</b>) Average tumor size (cm) with error bars showing stdev for resulting xenograft tumors following paired orthotropic injections of 786-0 cells containing either the control empty vector, pcDNA6 or hRor2 exhibited a trend to increased <i>in vivo</i> tumor growth with Ror2 overexpression. <b>D</b>) Average tumor size (mm) with error bars showing stdev for resulting xenograft tumors following subcutaneous injection of 786-0 cells containing either the control empty vector, GFP, wild-type Ror2, or Ror2-DM showed a significant increase in <i>in vivo</i> tumor growth with wild-type Ror2 overexpression. <i>P</i>-values were calculated using an Anova one-way analysis (*<.05 **<.01). <b>E</b>) Representative image of an orthotopic xenograft consisting of 786-0 vector control cells. <b>F</b>) Increased invasion of local tissues was evident with Ror2 expression, with arrows highlighting areas of continued invasion into the spleen.