Correlation between expression level of E2F6 and c-KIT in expression microarray dataset from TCGA ovarian cancer patients.

<p>Expression microarray data from 568 ovarian cancer patients are sorted according to the expression level of EZH2. The scatter plot demonstrates the correlation between expression level of E2F6 and c-KIT in ovarian cancer patients with (A) low EZH2 (bottom 12.5%) and (B) high EZH2 (top 12.5%). The R and P-value of the Pearson correlation are shown. Interestingly, as predicted by our model, patients with low EZH2 shows a positive correlation of E2F6 and c-KIT (A, R = 0.322, P<0.005). Such correlation is not observed in patients with high EZH2 (B, R = 0.2148. P>0.05). However, patients with high EZH2 can be further separated into 2 sub-groups based on the median value of c-KIT (high, red color; low, blue color). Neither of these sub-groups demonstrates a positive correlation between E2F6 and c-KIT.