The mTOR pathway is suppressed upon I/R injury both <i>in vivo</i> and <i>in vitro</i>.

<p>Representative western blots and the densitometric quantitative results of mTOR, p-mTOR, p-p70 S6 kinase(p-p70s6k), 4E-BP1(4ebp1) and p-4E-BP1(p-4ebp1) showing the expression levels in the retinas (A) and in the SH-SY5Y cell line (B) upon I/R injury. A, Equal amounts of protein from the control retinas and the I/R-treated retinas were loaded. Each lane represents individual retina (n = 4 in each group; *p<0.05 compared with the non-injured retinas). B, Equal amounts of protein from the control and the I/R-treated SH-SY5Y cell were loaded. Each lane means individual biological replicates (n = 3 in each group; *p<0.05 compared with the non-injured retinas). The error bars represent the standard error of the mean.